Boronic Esters
Boronic Esters
Boronic esters (RB(OR)2), also referred to as boronate esters, are formed between a boronic acid and an alcohol. Boronate esters are stable compounds, although the -C-B- bond of boronic ester is slightly longer than C-C single bonds. Boronic acid esters can undergo saponification and racemize optically active compounds. Boronic acid esters coordinate with basic molecules to form stable tetra-coordinated adducts. Boronic acid esters are considered as compounds for the designing of new drugs and drug delivery devices, more particularly as boron carriers for neutron capture therapy.
Boronic esters are very easy to purify and characterize. They have enhanced reactivity, higher compatibility with many reagents, better solubility in organic solvents, and are also used as good protecting groups to eliminate unwanted side reactions. Boronic acid ester molecules are used in pharmaceuticals, agrochemicals, and high-tech materials.
