Fmoc Protected Compounds
Fmoc Protected Compounds
Fmoc protected compounds contain the fluorenylmethoxycarbonyl group attached to the nitrogen atom of organic compounds. Fmoc chloride is a chloroformate ester, used to introduce Fmoc to amino compounds as Fmoc carbamate. A superior alternative for Fmoc protection is 9-fluorenylmethyl succinimidyl carbonate (Fmoc-OSu), also referred to as Fmoc succinimde, which prevents the formation of side products. The chemistry of Fmoc is used for the protection of the alpha amino group of amino acids. Fmoc chemistry has been shown to be more reliable for producing high quality peptides.
